hERG potassium channel inhibition by ivabradine requires channel gating.
نویسندگان
چکیده
منابع مشابه
hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine
BACKGROUND Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal HCN-channels. This study investigated the propensity of ivabradine to interact with KCNH2-encoded human Ether-à-go-go-Related Gene (hERG) potassium channels, which strongly influence ventricular repolarization and susceptibility to t...
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Human ether-à-go-go-related gene (HERG) potassium channels play an important role in cardiac action potential repolarization, and HERG dysfunction can cause cardiac arrhythmias. However, recent evidence suggests a role for HERG in the proliferation and progression of multiple types of cancers, making it an attractive target for cancer therapy. Ceramide is an important second messenger of the sp...
متن کاملhERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.
1 School of Physiology & Pharmacology, Medical Sciences Building, University Walk, Bristol, BS8 1TD. UK 2 School.of.Biochemistry, Medical Sciences Building, University Walk, Bristol, BS8 1TD, UK 3 Department of Cardiovascular Sciences, Cardiology group, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK 4 Department.of.Cell.Physiology.and.Pharmacology, Maurice Shock Medical Sci...
متن کاملGating currents associated with intramembrane charge displacement in HERG potassium channels.
HERG (human ether-a-go-go-related gene) encodes a delayed rectifier K+ channel vital to normal repolarization of cardiac action potentials. Attenuation of repolarizing K+ current caused by mutations in HERG or channel block by common medications prolongs ventricular action potentials and increases the risk of arrhythmia and sudden death. The critical role of HERG in maintenance of normal cardia...
متن کاملMechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine s
Ibogaine is a psychoactive indole alkaloid. Its use as an antiaddictive agent has been accompanied by QT prolongation and cardiac arrhythmias, which are most likely caused by human ether a go-go–related gene (hERG) potassium channel inhibition. Therefore, we studied in detail the interaction of ibogaine with hERG channels heterologously expressed in mammalian kidney tsA-201 cells. Currents thro...
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عنوان ژورنال:
- Journal of molecular and cellular cardiology
دوره 87 شماره
صفحات -
تاریخ انتشار 2015